Title |
A Drosophila Model Linking Diet-induced Obesity and Cancer (PQ 1)
|
Institution |
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY
|
Principal Investigator |
CAGAN, ROSS
|
NCI Program Director |
Spalholz
|
Cancer Activity |
Cancer Cell Biology
|
Division |
DCB
|
Funded Amount |
$341,162
|
Project Dates |
08/20/2012 - 05/31/2016
|
Fiscal Year |
2014
|
Project Type |
Grant
|
Research Topics w/ Percent Relevance |
Cancer Types w/ Percent Relevance |
Cancer (100.0%)
Digestive Diseases (100.0%)
|
Pancreas (100.0%)
|
Research Type |
Exogenous Factors in the Origin and Cause of Cancer
Application of Model Systems
|
Abstract |
DESCRIPTION (provided by applicant): Epidemiological studies have demonstrated that increased cancer risk is associated with obesity, but the underlying mechanism remains poorly understood. We have recently developed a Drosophila model of obesity; raising Drosophila on a diet high in carbohydrates led to metabolic dysfunction including hyperglycemia, insulin-resistance and accumulation of fat. Feeding a high dietary sucrose to Ras/Src co- activated Drosophila cancer model developed aggressive tumor with emergent metastasis in a diet-dependent manner. The goal of this Application is to further utilize Drosophila as a useful in situ model to explore mechanistic link between diet-induced obesity and tumor progression. |